Inhibitory Effects of 2'-Hydroxychalcones on Rat Lens Aldose Reductase and Rat Platelet Aggregation.
نویسندگان
چکیده
منابع مشابه
Aldose reductase in early streptozotocin-induced diabetic rat lens.
The present study investigates the status of lens aldose reductase in the early streptozotocin-induced diabetic rat. Aldose reductase protein concentration, protein synthesis, and enzyme activity was assayed at 3 days and 14 days post-streptozotocin injection. Our results indicated that there was no significant difference between normal (control) and diabetic rat lenses in these parameters duri...
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Background: The relationship between the high activity of aldose reductase (AR) and diabetic cataract formation has been previously investigated. The purpose of the present study was to determine the preventing effect of melatonin on streptozotocin (STZ)-induced diabetic cataract in rats.Methods: 34 adult healthy male Sprague-Dawely rats were divided into four groups. Diabetic control and diabe...
متن کاملinhibitory activity of flavonoids on the lens aldose reductase of healthy and diabetic rats
aldose reductase is a critical enzyme in the polyol pathway that plays an important role in diabetes mellitus. inhibition of the activity of this enzyme can prevent cataract in diabetic patients’lenses. in this study the inhibitory effect of two flavonoids, quercetin and naringin, in the activity of aldose reductase in streptozotocin-induced diabetic and healthy rats were investigated. thirty m...
متن کاملAnalysis of apigenin in Blumea balsamifera Linn DC. and its inhibitory activity against aldose reductase in rat lens
To investigate the therapeutic potentials of natural sources, stepwise polarity fractions of Blumea balsamifera were tested for their ability to inhibit aldose reductase (AR) activity in rat lenses. Of these, the ethyl acetate (EtOAc) fraction exhibited a unique AR inhibitory activity (IC50 value, 0.11 μg/mL). Apigenin was identified from the active EtOAc fraction and exhibited high AR inhibito...
متن کاملRapid Identification and Isolation of Inhibitors of Rat Lens Aldose Reductase and Antioxidant in Maackia amurensis
Oxidative stress and aldose reductase activity have been implicated in the development of diabetic complications. In this study, the antioxidant and aldose reductase (AR) inhibitory effects of Maackia amurensis (MA) were investigated. The ethyl acetate fraction of the MA extract showed the highest inhibitory activity in antioxidant and rat lens AR (RLAR). To identify and isolate the active comp...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2000
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.48.1786